Main Publications



Alessio N, Stellavato A, Squillaro T, Del Gaudio S, Di Bernardo G, Peluso G, De Rosa M, Schiraldi C, Galderisi U. Hybrid complexes of high and low molecular  weight hyaluronan delay in vitro replicative senescence of mesenchymal stromal cells: a pilot study for future therapeutic application. Aging (Albany NY). 2018  Jul 12. doi: 10.18632/aging.101493. [Epub ahead of print] PubMed PMID: 30001217.


Alessio N, Pipino C, Mandatori D, Di Tomo P, Ferone A, Marchiso M, Melone MAB, Peluso G, Pandolfi A, Galderisi U. Mesenchymal stromal cells from amniotic fluid  are less prone to senescence compared to those obtained from bone marrow: An in vitro study. J Cell Physiol. 2018 Jun 15. doi: 10.1002/jcp.26845. [Epub ahead of print] PubMed PMID: 29904927.


Alessio N, Squillaro T, Özcan S, Di Bernardo G, Venditti M, Melone M, Peluso G, Galderisi U. Stress and stem cells: adult Muse cells tolerate extensive genotoxic stimuli better than mesenchymal stromal cells. Oncotarget. 2018 Apr 10;9(27):19328-19341. doi: 10.18632/oncotarget.25039. eCollection 2018 Apr 10. PubMed PMID: 29721206; PubMed Central PMCID: PMC5922400.


Squillaro T, Galano G, De Rosa R, Peluso G, Galderisi U. Concise Review: The Effect of Low-Dose Ionizing Radiation on Stem Cell Biology: A Contribution to Radiation Risk. Stem Cells. 2018 Apr 17. doi: 10.1002/stem.2836. [Epub ahead of print]. PubMed PMID: 29664142.


Cuomo F, Coppola A, Botti C, Maione C, Forte A, Scisciola L, Liguori G, Caiafa I, Ursini MV, Galderisi U, Cipollaro M, Altucci L, Cobellis G. Pro-inflammatory cytokines activate hypoxia-inducible factor 3α via epigenetic changes in mesenchymal stromal/stem cells. Sci Rep. 2018 Apr 11;8(1):5842. doi: 10.1038/s41598-018-24221-5. PubMed PMID: 29643458; PubMed Central PMCID: PMC5895792.


Alessio N, Riccitiello F, Squillaro T, Capasso S, Del Gaudio S, Di Bernardo G, Cipollaro M, Melone MAB, Peluso G, Galderisi U. Neural stem cells from a mouse model of Rett syndrome are prone to senescence, show reduced capacity to cope with genotoxic stress, and are impaired in the differentiation process. Exp Mol Med. 2018 Mar 22;50(3):1. doi: 10.1038/s12276-017-0005-x. PubMed PMID: 29563495.


Melone MAB, Valentino A, Margarucci S, Galderisi U, Giordano A, Peluso G. The  carnitine system and cancer metabolic plasticity. Cell Death Dis. 2018 Feb 14;9(2):228. doi: 10.1038/s41419-018-0313-7. Review. PubMed PMID: 29445084; PubMed Central PMCID: PMC5833840.


Squillaro T, Schettino C, Sampaolo S, Galderisi U, Di Iorio G, Giordano A, Melone MAB. Adult-onset brain tumors and neurodegeneration: Are polyphenols protective? J Cell Physiol. 2018 May;233(5):3955-3967. doi: 10.1002/jcp.26170. Epub 2017 Sep 28. Review. PubMed PMID: 28884813.


Alessio N, Capasso S, Ferone A, Di Bernardo G, Cipollaro M, Casale F, Peluso G, Giordano A, Galderisi U. Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence. Neoplasia. 2017 Oct;19(10):781-790. doi: 10.1016/j.neo.2017.06.005. Epub 2017 Aug 30. PubMed PMID: 28865301; PubMed Central PMCID: PMC5577395.


Valentino A, Calarco A, Di Salle A, Finicelli M, Crispi S, Calogero RA, Riccardo F, Sciarra A, Gentilucci A, Galderisi U, Margarucci S, Peluso G. Deregulation of MicroRNAs mediated control of carnitine cycle in prostate cancer: molecular basis and pathophysiological consequences. Oncogene. 2017 Oct 26;36(43):6030-6040. doi: 10.1038/onc.2017.216. Epub 2017 Jul 3. PubMed PMID: 28671672.


Alessio N, Esposito G, Galano G, De Rosa R, Anello P, Peluso G, Tabocchini MA, Galderisi U. Irradiation of Mesenchymal Stromal Cells With Low and High Doses of Alpha Particles Induces Senescence and/or Apoptosis. J Cell Biochem. 2017 Sep;118(9):2993-3002. doi: 10.1002/jcb.25961. Epub 2017 May 3. PubMed PMID: 28252222.


Mucerino S, Di Salle A, Alessio N, Margarucci S, Nicolai R, Melone MA, Galderisi U, Peluso G. Alterations in the carnitine cycle in a mouse model of Rett syndrome. Sci Rep. 2017 Feb 2;7:41824. doi: 10.1038/srep41824. PubMed PMID:  28150739; PubMed Central PMCID: PMC5288798.


Albinsson S, Della Corte A, Alajbegovic A, Krawczyk KK, Bancone C, Galderisi U, Cipollaro M, De Feo M, Forte A. Patients with bicuspid and tricuspid aortic valve exhibit distinct regional microrna signatures in mildly dilated ascending aorta. Heart Vessels. 2017 Jan 19. doi: 10.1007/s00380-016-0942-7. [Epub ahead of print] PubMed PMID: 28102444.


Squillaro T, Antonucci I, Alessio N, Esposito A, Cipollaro M, Melone MA, Peluso G, Stuppia L, Galderisi U. Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes. J Cell Physiol. 2017 Jan 18. doi: 10.1002/jcp.25807. [Epub ahead of print] PubMed PMID: 28098348.


Messina G, Di Bernardo G, Viggiano A, De Luca V, Monda V, Messina A, Chieffi S, Galderisi U, Monda M. Exercise increases the level of plasma orexin A in humans. J Basic Clin Physiol Pharmacol. 2016 Nov 1;27(6):611-616. doi: 10.1515/jbcpp-2015-0133. PubMed PMID: 27665420.


Alessio N, Özcan S, Tatsumi K, Murat A, Peluso G, Dezawa M, Galderisi U. The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation. Cell Cycle. 2017 Jan 2;16(1):33-44. doi: 10.1080/15384101.2016.1211215. Epub 2016 Jul 27. PubMed PMID: 27463232; PubMed Central PMCID: PMC5270533.


Forte A, Galderisi U, Cipollaro M, De Feo M, Corte AD. Epigenetic regulation of TGF-β1 signalling in dilative aortopathy of the thoracic ascending aorta. Clin Sci (Lond). 2016 Aug 1;130(16):1389-405. doi: 10.1042/CS20160222. Review. PubMed  PMID: 27389586.


Özcan S, Alessio N, Acar MB, Mert E, Omerli F, Peluso G, Galderisi U. Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses. Aging (Albany NY). 2016 Jul;8(7):1316-29. doi: 10.18632/aging.100971. PubMed PMID: 27288264.


Ozkul Y, Galderisi U. The Impact of Epigenetics on Mesenchymal Stem Cell Biology. J Cell Physiol. 2016 Nov;231(11):2393-401. doi: 10.1002/jcp.25371. Epub  2016 Apr 4. PubMed PMID: 26960183.


Squillaro T, Peluso G, Galderisi U. Clinical Trials With Mesenchymal Stem Cells: An Update. Cell Transplant. 2016;25(5):829-48. doi: 10.3727/096368915X689622. Epub 2015 Sep 29. PubMed PMID: 26423725.


Özcan S, Alessio N, Acar MB, Toprak G, Gönen ZB, Peluso G, Galderisi U.  Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity. Oncotarget. 2015 Nov 24;6(37):39482-92. doi: 10.18632/oncotarget.5430. PubMed PMID: 26498687 


Alessio N, Del Gaudio S, Capasso S, Di Bernardo G, Cappabianca S, Cipollaro M, Peluso G, Galderisi U. Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process. Oncotarget. 2015 Apr 10;6(10):8155-66. PubMed PMID: 25544750; PubMed Central PMCID: PMC4480742.

Squillaro T, Severino V, Alessio N, Farina A, Di Bernardo G, Cipollaro M, Peluso G, Chambery A, Galderisi U. De-regulated expression of the BRG1 chromatin  remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins. Cell Cycle. 2015;14(8):1315-26. doi: 10.4161/15384101.2014.995053. PubMed PMID: 25724006.

Galderisi U, Giordano A. The Gap Between the Physiological and Therapeutic Roles of Mesenchymal Stem Cells. Med Res Rev. 2014 May 28. doi: 10.1002/med.21322. [Epub ahead of print] PubMed PMID: 24866817.

Rinaldi B, Finicelli M, Donniacuo M, Di Bernardo G, Gritti G, Del Gaudio S, Forte A, Peluso G, Cipollaro M, Rossi F, Galderisi U. G-CSF Contributes at the Healing of Tunica Media of Arteriotomy-Injured Rat Carotids by Promoting Differentiation of Vascular Smooth Muscle Cells. J Cell Physiol. 2015 Jun 10. doi: 10.1002/jcp.25074. [Epub ahead of print] PubMed PMID: 26096962.

Finicelli M, Benedetti G, Squillaro T, Pistilli B, Marcellusi A, Mariani P, Santinelli A, Latini L, Galderisi U, Giordano A. Expression of stemness genes in  primary breast cancer tissues: the role of SOX2 as a prognostic marker for detection of early recurrence. Oncotarget. 2014 Oct 30;5(20):9678-88. PubMed PMID: 25127259; PubMed Central PMCID: PMC4259429.

Forte A, Rinaldi B, Berrino L, Rossi F, Galderisi U, Cipollaro M. Novel potential targets for prevention of arterial restenosis: insights from the pre-clinical research. Clin Sci (Lond). 2014 Dec;127(11):615-34. doi: 10.1042/CS20140131. Review. PubMed PMID: 25072327.
Cirillo A, Di Salle A, Petillo O, Melone MA, Grimaldi G, Bellotti A, Torelli G, De' Santi MS, Cantatore G, Galderisi U, Peluso G. High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism. Cancer  Biol Ther. 2014 Mar 11;15(6). [Epub ahead of print] PubMed PMID: 24618825.
Di Bernardo G, Messina G, Capasso S, Del Gaudio S, Cipollaro M, Peluso G, Casale F, Monda M, Galderisi U. Sera of overweight people promote in vitro adipocyte differentiation of bone marrow stromal cells. Stem Cell Res Ther. 2014  Jan 9;5(1):4. [Epub ahead of print] PubMed PMID: 24405848.
Capasso S, Alessio N, Di Bernardo G, Cipollaro M, Melone MA, Peluso G, Giordano A, Galderisi U. Silencing of RB1 and RB2/P130 during adipogenesis of bone marrow stromal cells results in dysregulated differentiation. Cell Cycle. 2014 Feb 1;13(3):482-90. doi: 10.4161/cc.27275. Epub 2013 Nov 26. PubMed PMID: 24281253; PubMed Central PMCID: PMC3956544.
Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A. Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells. Cell Death Dis. 2013 Nov 7;4:e911. doi: 10.1038/cddis.2013.445. PubMed PMID: 24201810.
Del Gaudio S, Cirillo A, Di Bernardo G, Galderisi U, Thanassoulas T, Pitsios T, Cipollaro M. Preamplification procedure for the analysis of ancient DNA samples. ScientificWorldJournal. 2013 Sep 25;2013:734676. doi: 10.1155/2013/734676. PubMed PMID: 24187523; PubMed Central PMCID: PMC3800654.
Forte A, Cipollaro M, Galderisi U. Genetic, epigenetic and stem cell alterations in endometriosis: new insights and potential therapeutic perspectives. Clin Sci (Lond). 2014 Jan;126(2):123-38. doi: 10.1042/CS20130099. PubMed PMID: 24059589.
Alessio N, Bohn W, Rauchberger V, Rizzolio F, Cipollaro M, Rosemann M, Irmler M, Beckers J, Giordano A, Galderisi U. Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells. Cell Mol Life Sci. 2013 May;70(9):1637-51. doi: 10.1007/s00018-012-1224-x. Epub 2013 Jan 31. PubMed PMID: 23370776.
Calarco A, Bosetti M, Margarucci S, Fusaro L, Nicolì E, Petillo O, Cannas M, Galderisi U, Peluso G. The genotoxicity of PEI-based nanoparticles is reduced by  acetylation of polyethylenimine amines in human primary cells. Toxicol Lett. 2013 Mar 27;218(1):10-7. doi: 10.1016/j.toxlet.2012.12.019. Epub 2013 Jan 4. PubMed PMID: 23296103.
Forte A, Della Corte A, Grossi M, Bancone C, Maiello C, Galderisi U, Cipollaro M. Differential expression of proteins related to smooth muscle cells and myofibroblasts in human thoracic aortic aneurysm. Histol Histopathol. 2013 Jun;28(6):795-803. Epub 2012 Dec 27. PubMed PMID: 23269611.
Galderisi U, Peluso G, Di Bernardo G, Calarco A, D'Apolito M, Petillo O, Cipollaro M, Fusco FR, Melone MA. Efficient cultivation of neural stem cells with controlled delivery of FGF-2. Stem Cell Res. 2013 Jan;10(1):85-94. doi: 10.1016/j.scr.2012.09.001. Epub 2012 Sep 26. PubMed PMID: 23142801.
Melone MA, Calarco A, Petillo O, Margarucci S, Colucci-D'Amato L, Galderisi U, Koverech G, Peluso G. Mutant huntingtin regulates EGF receptor fate in non-neuronal cells lacking wild-type protein. Biochim Biophys Acta. 2013 Jan;1832(1):105-13. doi: 10.1016/j.bbadis.2012.09.001. Epub 2012 Sep 10. PubMed PMID: 22974559.
Di Bernardo G, Piva R, Giordano A, Galderisi U. Exploiting stem cell therapy: the 3rd meeting of stem cell research Italy. J Cell Physiol. 2013 Apr;228(4):911-4. doi: 10.1002/jcp.24216. PubMed PMID: 22927167.
Forte A, Della Corte A, Grossi M, Bancone C, Provenzano R, Finicelli M, De Feo M, De Santo LS, Nappi G, Cotrufo M, Galderisi U, Cipollaro M. Early cell changes and TGFbeta pathway alterations in the aortopathy associated with bicuspid aortic valve stenosis. Clin Sci (Lond). 2013 Jan;124(2):97-108 PubMed PMID: 22857993.

Zanichelli F, Capasso S, Di Bernardo G, Cipollaro M, Pagnotta E, Cartenì M, Casale F, Iori R, Giordano A, Galderisi U. Low concentrations of isothiocyanates  protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage. Apoptosis. 2012 Sep;17(9):964-74. doi: 10.1007/s10495-012-0740-3. PubMed PMID: 22684843.

Squillaro T, Alessio N, Cipollaro M, Melone MA, Hayek G, Renieri A, Giordano A, Galderisi U. Reduced expression of MECP2 affects cell commitment and maintenance in neurons by triggering senescence: new perspective for Rett syndrome. Mol Biol Cell. 2012 Apr;23(8):1435-45. doi: 10.1091/mbc.E11-09-0784. Epub 2012 Feb 22. PubMed PMID: 22357617; PubMed Central PMCID: PMC3327309.

Di Bernardo G, Cipollaro M, Galderisi U. Chromatin modification and senescence. Curr Pharm Des. 2012;18(13):1686-93. Review. PubMed PMID: 22352755.

Forte A, Rinaldi B, Sodano L, Berrino L, Rossi F, Finicelli M, Grossi M, Cobellis G, Botti C, De Feo M, Santè P, Galderisi U, Cipollaro M. Stem cell therapy for arterial restenosis: potential parameters contributing to the success of bone marrow-derived mesenchymal stromal cells. Cardiovasc Drugs Ther. 2012 Feb;26(1):9-21. doi: 10.1007/s10557-011-6359-8. PubMed PMID: 22167462.

Siniscalco D, Giordano C, Galderisi U, Luongo L, de Novellis V, Rossi F, Maione S. Long-lasting effects of human mesenchymal stem cell systemic administration on pain-like behaviors, cellular, and biomolecular modifications in neuropathic mice. Front Integr Neurosci. 2011;5:79. doi: 10.3389/fnint.2011.00079. Epub 2011 Dec 1. PubMed PMID: 22164136; PubMed Central  PMCID: PMC3230031.

Forte A, Della Corte A, Grossi M, Finicelli M, Bancone C, Provenzano R, Pepino P, Nappi GA, De Feo M, Galderisi U, Cotrufo M, Cipollaro M. Morphological  and molecular characterization of healthy human ascending aorta. Histol Histopathol. 2012 Jan;27(1):103-12. PubMed PMID: 22127602.

Siniscalco D, Pandolfi A, Galderisi U. State-of-the-art on basic and applied  stem cell therapy; Stem Cell Research Italy-International Society for Cellular Therapy Europe, Joint Meeting, Montesilvano (PE)-Italy, June 10-12, 2011. Stem Cells Dev. 2012 Mar 20;21(5):668-9. doi: 10.1089/scd.2011.0609. Epub 2011 Dec 23. PubMed PMID: 22035042.

Siniscalco D, Giordano A, Galderisi U. Novel insights in basic and applied stem cell therapy. J Cell Physiol. 2012 May;227(5):2283-6. doi: 10.1002/jcp.22945. PubMed PMID: 21780112.

Helmbold H, Galderisi U, Bohn W. The switch from pRb/p105 to Rb2/p130 in DNA  damage and cellular senescence. J Cell Physiol. 2012 Feb;227(2):508-13. doi: 10.1002/jcp.22786. Review. PubMed PMID: 21465484.

Zanichelli F, Capasso S, Cipollaro M, Pagnotta E, Cartenì M, Casale F, Iori R, Galderisi U. Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect. Age (Dordr). 2012 Apr;34(2):281-93. doi: 10.1007/s11357-011-9231-7. Epub 2011 Apr 6. PubMed PMID: 21465338; PubMed Central PMCID: PMC3312628.

Galderisi U. Stem cell research Italy: genesis of a society. Stem Cells Dev.  2010 Nov;19(11):1649. doi: 10.1089/scd.2010.0238. Epub 2010 Oct 9. PubMed PMID: 20932188.

Alessio N, Squillaro T, Cipollaro M, Bagella L, Giordano A, Galderisi U. The  BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB-P53 pathways. Oncogene. 2010 Oct 7;29(40):5452-63. doi: 10.1038/onc.2010.285. Epub 2010 Aug 9. PubMed PMID: 20697355.

Calarco A, Petillo O, Bosetti M, Torpedine A, Cannas M, Perrone L, Galderisi  U, Melone MA, Peluso G. Controlled delivery of the heparan sulfate/FGF-2 complex  by a polyelectrolyte scaffold promotes maximal hMSC proliferation and differentiation. J Cell Biochem. 2010 Jul 1;110(4):903-9. doi: 10.1002/jcb.22602. PubMed PMID: 20564189.

Di Bernardo G, Alessio N, Dell'Aversana C, Casale F, Teti D, Cipollaro M, Altucci L, Galderisi U. Impact of histone deacetylase inhibitors SAHA and MS-275  on DNA repair pathways in human mesenchymal stem cells. J Cell Physiol. 2010 Nov;225(2):537-44. doi: 10.1002/jcp.22236. PubMed PMID: 20458754.

Galderisi U, Giordano A, Paggi MG. The bad and the good of mesenchymal stem cells in cancer: Boosters of tumor growth and vehicles for targeted delivery of anticancer agents. World J Stem Cells. 2010 Feb 26;2(1):5-12. doi:10.4252/wjsc.v2.i1.5. PubMed PMID: 21607110; PubMed Central PMCID: PMC3097917.

Symonds CE, Galderisi U, Giordano A. Aging of the inceptive cellular population: the relationship between stem cells and aging. Aging (Albany NY). 2009 Apr 2;1(4):372-81. Review. PubMed PMID: 20157525; PubMed Central PMCID: PMC2806020.

Squillaro T, Alessio N, Cipollaro M, Renieri A, Giordano A, Galderisi U. Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA. FASEB J. 2010 May;24(5):1593-603. doi: 10.1096/fj.09-143057. Epub 2010 Jan 11. PubMed PMID: 20065105.

Siniscalco D, Giordano C, Galderisi U, Luongo L, Alessio N, Di Bernardo G, de Novellis V, Rossi F, Maione S. Intra-brain microinjection of human mesenchymal stem cells decreases allodynia in neuropathic mice. Cell Mol Life Sci. 2010 Feb;67(4):655-69. doi: 10.1007/s00018-009-0202-4. Epub 2009 Nov 24. PubMed PMID:  19937263.

Di Bernardo G, Galderisi U, Fiorito C, Squillaro T, Cito L, Cipollaro M, Giordano A, Napoli C. Dual role of parathyroid hormone in endothelial progenitor  cells and marrow stromal mesenchymal stem cells. J Cell Physiol. 2010 Feb;222(2):474-80. doi: 10.1002/jcp.21976. PubMed PMID: 19918796.

Del Gaudio S, Cirillo A, Di Bernardo G, Galderisi U, Cipollaro M. A preamplification approach to GMO detection in processed foods. Anal Bioanal Chem. 2010 Mar;396(6):2135-42. doi: 10.1007/s00216-009-3199-5. Epub 2009 Oct 13. PubMed PMID: 19823811.

Forte A, Finicelli M, Grossi M, Vicchio M, Alessio N, Santè P, De Feo M, Cotrufo M, Berrino L, Rossi F, Galderisi U, Cipollaro M. DNA damage and repair in a model of rat vascular injury. Clin Sci (Lond). 2009 Oct 5. [Epub ahead of print] PubMed PMID: 19804370.

Forte A, Schettino MT, Finicelli M, Cipollaro M, Colacurci N, Cobellis L, Galderisi U. Expression pattern of stemness-related genes in human endometrial and endometriotic tissues. Mol Med. 2009 Nov-Dec;15(11-12):392-401. doi: 10.2119/molmed.2009.00068. Epub 2009 Aug 10. PubMed PMID: 19690622; PubMed Central PMCID: PMC2727462.

Forte A, Galderisi U, Cipollaro M, Cascino A. Mesenchymal stem cells: a good  candidate for restenosis therapy? Curr Vasc Pharmacol. 2009 Jul;7(3):381-93. Review. PubMed PMID: 19601863.

Di Bernardo G, Del Gaudio S, Galderisi U, Cascino A, Cipollaro M. Ancient DNA and family relationships in a Pompeian house. Ann Hum Genet. 2009 Jul;73(Pt 4):429-37. doi: 10.1111/j.1469-1809.2009.00520.x. PubMed PMID: 19523150.

Melone MA, Giuliano M, Squillaro T, Alessio N, Casale F, Mattioli E, Cipollaro M, Giordano A, Galderisi U. Genes involved in regulation of stem cell properties: studies on their expression in a small cohort of neuroblastoma patients. Cancer Biol Ther. 2009 Jul;8(13):1300-6. PubMed PMID: 19458492.

Galderisi U, Helmbold H, Squillaro T, Alessio N, Komm N, Khadang B, Cipollaro M, Bohn W, Giordano A. In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes. Stem Cells Dev. 2009 Sep;18(7):1033-42. doi: 10.1089/scd.2008.0324. PubMed PMID:  19099372.

Forte A, Finicelli M, De Luca P, Quarto C, Onorati F, Santè P, Renzulli A, Galderisi U, Berrino L, De Feo M, Rossi F, Cotrufo M, Cascino A, Cipollaro M. Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation. J Cell Mol Med. 2008 Oct;12(5B):1956-73. doi: 10.1111/j.1582-4934.2008.00212.x. PubMed PMID: 19012726.

Tirino V, Desiderio V, d'Aquino R, De Francesco F, Pirozzi G, Graziano A, Galderisi U, Cavaliere C, De Rosa A, Papaccio G, Giordano A. Detection and characterization of CD133+ cancer stem cells in human solid tumours. PLoS One. 2008;3(10):e3469. doi: 10.1371/journal.pone.0003469. Epub 2008 Oct 21. Erratum in: PLoS ONE. 2008;3(12). doi: 10.1371/annotation/6475ab87-5c24-4ee6-9989-0762186dd073. Graziano, Antonio [added]; Giordano, Antonio [added]. PubMed PMID: 18941626; PubMed Central PMCID:  PMC2565108.

Di Bernardo G, Squillaro T, Dell'Aversana C, Miceli M, Cipollaro M, Cascino A, Altucci L, Galderisi U. Histone deacetylase inhibitors promote apoptosis and senescence in human mesenchymal stem cells. Stem Cells Dev. 2009 May;18(4):573-81. doi: 10.1089/scd.2008.0172. PubMed PMID: 18694296.

Forte A, Finicelli M, Mattia M, Berrino L, Rossi F, De Feo M, Cotrufo M, Cipollaro M, Cascino A, Galderisi U. Mesenchymal stem cells effectively reduce surgically induced stenosis in rat carotids. J Cell Physiol. 2008 Dec;217(3):789-99. doi: 10.1002/jcp.21559. PubMed PMID: 18690654.

Forte A, Finicelli M, De Luca P, Nordström I, Onorati F, Quarto C, Santè P, Renzulli A, Galderisi U, Berrino L, De Feo M, Hellstrand P, Rossi F, Cotrufo M, Cascino A, Cipollaro M. Injury to rat carotid arteries causes time-dependent changes in gene expression in contralateral uninjured arteries. Clin Sci (Lond).  2009 Jan;116(2):125-36. doi: 10.1042/CS20080080. PubMed PMID: 18522534.

Squillaro T, Hayek G, Farina E, Cipollaro M, Renieri A, Galderisi U. A case report: bone marrow mesenchymal stem cells from a Rett syndrome patient are prone to senescence and show a lower degree of apoptosis. J Cell Biochem. 2008 Apr 15;103(6):1877-85. PubMed PMID: 18059018.

Napolitano MA, Cipollaro M, Cascino A, Melone MA, Giordano A, Galderisi U. Brg1 chromatin remodeling factor is involved in cell growth arrest, apoptosis and senescence of rat mesenchymal stem cells. J Cell Sci. 2007 Aug 15;120(Pt 16):2904-11. Epub 2007 Jul 31. PubMed PMID: 17666433.

Forte A, Cipollaro M, Cascino A, Galderisi U. Pathophysiology of stem cells in restenosis. Histol Histopathol. 2007 May;22(5):547-57. Review. PubMed PMID: 17330810.

Di Bernardo G, Del Gaudio S, Galderisi U, Cascino A, Cipollaro M. Comparative evaluation of different DNA extraction procedures from food samples. Biotechnol Prog. 2007 Mar-Apr;23(2):297-301. Epub 2007 Feb 8. Review. PubMed PMID: 17286386.

Giordano A, Galderisi U, Marino IR. From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells. J Cell Physiol. 2007 Apr;211(1):27-35. Review. PubMed PMID: 17226788.

Jori FP, Galderisi U, Napolitano MA, Cipollaro M, Cascino A, Giordano A, Melone MA. RB and RB2/P130 genes cooperate with extrinsic signals to promote differentiation of rat neural stem cells. Mol Cell Neurosci. 2007 Mar;34(3):299-309. Epub 2007 Jan 12. PubMed PMID: 17223573.

Pelaia G, Gallelli L, D'Agostino B, Vatrella A, Cuda G, Fratto D, Renda T, Galderisi U, Piegari E, Crimi N, Rossi F, Caputi M, Costanzo FS, Vancheri C, Maselli R, Marsico SA. Effects of TGF-beta and glucocorticoids on map kinase phosphorylation, IL-6/IL-11 secretion and cell proliferation in primary cultures  of human lung fibroblasts. J Cell Physiol. 2007 Feb;210(2):489-97. PubMed PMID: 17044077.

Galderisi U, Cipollaro M, Giordano A. The retinoblastoma gene is involved in  multiple aspects of stem cell biology. Oncogene. 2006 Aug 28;25(38):5250-6. Review. PubMed PMID: 16936744.

Forte A, Napolitano MA, Cipollaro M, Giordano A, Cascino A, Galderisi U. An effective method for adenoviral-mediated delivery of small interfering RNA into mesenchymal stem cells. J Cell Biochem. 2007 Feb 1;100(2):293-302. PubMed PMID: 16888813.

Forte A, Galderisi U, De Feo M, Quarto C, Renzulli A, Berrino L, Rossi F, Cascino A, Cipollaro M. Carotid arteriotomy induces different temporal gene expression profiles in normotensive and hypertensive rat strains. Int J Mol Med.  2005 Dec;16(6):1057-64. PubMed PMID: 16273286.

Gallelli L, Pelaia G, D'Agostino B, Cuda G, Vatrella A, Fratto D, Gioffrè V,  Galderisi U, De Nardo M, Mastruzzo C, Salinaro ET, Maniscalco M, Sofia M, Crimi N, Rossi F, Caputi M, Costanzo FS, Maselli R, Marsico SA, Vancheri C. Endothelin-1 induces proliferation of human lung fibroblasts and IL-11 secretion  through an ET(A) receptor-dependent activation of MAP kinases. J Cell Biochem. 2005 Nov 1;96(4):858-68. PubMed PMID: 16149067.

Galderisi U, Cipollaro M, Giordano A. Stem cells and brain cancer. Cell Death Differ. 2006 Jan;13(1):5-11. Review. PubMed PMID: 16123777.

Galderisi U, Cipollaro M, Cascino A. Clinical trials of a new class of therapeutic agents: antisense oligonucleotides. Expert Opin Emerg Drugs. 2001Apr;6(1):69-79. PubMed PMID: 15989497.

Forte A, Galderisi U, De Feo M, Gomez MF, Esposito S, Santè P, Renzulli A, Agozzino L, Hellstrand P, Berrino L, Cipollaro M, Cotrufo M, Rossi F, Cascino A.  c-Myc antisense oligonucleotides preserve smooth muscle differentiation and reduce negative remodelling following rat carotid arteriotomy. J Vasc Res. 2005 May-Jun;42(3):214-25. Epub 2005 Apr 20. PubMed PMID: 15849475.

Di Bernardo G, Galderisi U, Cipollaro M, Cascino A. Methods to improve the yield and quality of DNA from dried and processed figs. Biotechnol Prog. 2005 Mar-Apr;21(2):546-9. PubMed PMID: 15801796.

D'Argenio G, Calvani M, Della Valle N, Cosenza V, Di Matteo G, Giorgio P, Margarucci S, Petillo O, Jori FP, Galderisi U, Peluso G. Differential expression of multiple transglutaminases in human colon: impaired keratinocytetransglutaminase expression in ulcerative colitis. Gut. 2005 Apr;54(4):496-502. PubMed PMID: 15753534; PubMed Central PMCID: PMC1774462.

Forte A, Cipollaro M, Cascino A, Galderisi U. Small interfering RNAs and antisense oligonucleotides for treatment of neurological diseases. Curr Drug Targets. 2005 Feb;6(1):21-9. Review. PubMed PMID: 15720210.

Jori FP, Napolitano MA, Melone MA, Cipollaro M, Cascino A, Altucci L, Peluso  G, Giordano A, Galderisi U. Molecular pathways involved in neural in vitro differentiation of marrow stromal stem cells. J Cell Biochem. 2005 Mar 1;94(4):645-55. PubMed PMID: 15547939.

Di Bernardo G, Del Gaudio S, Galderisi U, Cipollaro M. 2000 Year-old ancient  equids: an ancient-DNA lesson from pompeii remains. J Exp Zool B Mol Dev Evol. 2004 Nov 15;302(6):550-6. PubMed PMID: 15468050.

Jori FP, Melone MA, Napolitano MA, Cipollaro M, Cascino A, Giordano A, Galderisi U. RB and RB2/p130 genes demonstrate both specific and overlapping functions during the early steps of in vitro neural differentiation of marrow stromal stem cells. Cell Death Differ. 2005 Jan;12(1):65-77. PubMed PMID: 15459751.

Cipollaro M, Galderisi U, Di Bernardo G. Ancient DNA as a multidisciplinary experience. J Cell Physiol. 2005 Feb;202(2):315-22. Review. PubMed PMID: 15389521.

Jori FP, Napolitano MA, Melone MA, Cipollaro M, Cascino A, Giordano A, Galderisi U. Role of RB and RB2/P130 genes in marrow stromal stem cells plasticity. J Cell Physiol. 2004 Aug;200(2):201-12. PubMed PMID: 15174090.

Di Bernardo G, Galderisi U, Del Gaudio S, D'Aniello A, Lanave C, De Robertis  MT, Cascino A, Cipollaro M. Genetic characterization of Pompeii and Herculaneum Equidae buried by Vesuvius in 79 AD. J Cell Physiol. 2004 May;199(2):200-5. PubMed PMID: 15040002.

de Novellis V, Siniscalco D, Galderisi U, Fuccio C, Nolano M, Santoro L, Cascino A, Roth KA, Rossi F, Maione S. Blockade of glutamate mGlu5 receptors in a rat model of neuropathic pain prevents early over-expression of pro-apoptotic genes and morphological changes in dorsal horn lamina II. Neuropharmacology. 2004 Mar;46(4):468-79. PubMed PMID: 14975670.

Forte A, Esposito S, De Feo M, Galderisi U, Quarto C, Esposito F, Renzulli A, Berrino L, Cipollaro M, Agozzino L, Cotrufo M, Rossi F, Cascino A. Stenosis progression after surgical injury in Milan hypertensive rat carotid arteries. Cardiovasc Res. 2003 Dec 1;60(3):654-63. PubMed PMID: 14659811.

Galderisi U, Jori FP, Giordano A. Cell cycle regulation and neural differentiation. Oncogene. 2003 Aug 11;22(33):5208-19. Review. PubMed PMID: 12910258.

Jori FP, Galderisi U, Piegari E, Cipollaro M, Cascino A, Peluso G, Cotrufo R, Giordano A, Melone MA. EGF-responsive rat neural stem cells: molecular follow-up  of neuron and astrocyte differentiation in vitro. J Cell Physiol. 2003 May;195(2):220-33. PubMed PMID: 12652649.

Forte A, Di Micco G, Galderisi U, De Feo M, Esposito F, Esposito S, Renzulli  A, Berrino L, Cipollaro M, Agozzino L, Cotrufo M, Rossi F, Cascino A. Gene expression and morphological changes in surgically injured carotids of spontaneously hypertensive rats. J Vasc Res. 2002 Mar-Apr;39(2):114-21. PubMed PMID: 12011583.

Maione S, Siniscalco D, Galderisi U, de Novellis V, Uliano R, Di Bernardo G,  Berrino L, Cascino A, Rossi F. Apoptotic genes expression in the lumbar dorsal horn in a model neuropathic pain in rat. Neuroreport. 2002 Jan 21;13(1):101-6. PubMed PMID: 11924868.

Di Bernardo G, Del Gaudio S, Cammarota M, Galderisi U, Cascino A, Cipollaro M. Enzymatic repair of selected cross-linked homoduplex molecules enhances nuclear gene rescue from Pompeii and Herculaneum remains. Nucleic Acids Res. 2002 Feb 15;30(4):e16. PubMed PMID: 11842122; PubMed Central PMCID: PMC100355.

Jori FP, Galderisi U, Piegari E, Peluso G, Cipollaro M, Cascino A, Giordano A, Melone MA. RB2/p130 ectopic gene expression in neuroblastoma stem cells: evidence of cell-fate restriction and induction of differentiation. Biochem J. 2001 Dec 15;360(Pt 3):569-77. PubMed PMID: 11736646; PubMed Central PMCID: PMC1222259.

Galderisi U, Melone MA, Jori FP, Piegari E, Di Bernardo G, Cipollaro M, Cascino A, Peluso G, Claudio PP, Giordano A. pRb2/p130 gene overexpression induces astrocyte differentiation. Mol Cell Neurosci. 2001 Mar;17(3):415-25. PubMed PMID: 11273639.

Forte A, Di Micco G, Galderisi U, Guarino FM, Cipollaro M, De Feo M, Gregorio R, Bianco MR, Vollono C, Esposito F, Berrino L, Angelini F, Renzulli A, Cotrufo M, Rossi F, Cascino A. Molecular analysis of arterial stenosis in rat carotids. J Cell Physiol. 2001 Feb;186(2):307-13. PubMed PMID: 11169467.

Melone MA, Peluso G, Galderisi U, Petillo O, Cotrufo R. Increased expression  of IGF-binding protein-5 in Duchenne muscular dystrophy (DMD) fibroblasts correlates with the fibroblast-induced downregulation of DMD myoblast growth: an  in vitro analysis. J Cell Physiol. 2000 Oct;185(1):143-53. PubMed PMID: 10942528.

Piegari E, Galderisi U, Berrino L, Di Bernardo G, Cipollaro M, Esposito F, Rossi F, Cascino A. In vivo effects of partial phosphorothioated AT1 receptor antisense oligonucleotides in spontaneously hypertensive and normotensive rats. Life Sci. 2000 Apr 14;66(21):2091-9. PubMed PMID: 10823348.

Melone MA, Peluso G, Petillo O, Galderisi U, Cotrufo R. Defective growth in vitro of Duchenne Muscular Dystrophy myoblasts: the molecular and biochemical basis. J Cell Biochem. 1999 Nov;76(1):118-32. PubMed PMID: 10581006.

Galderisi U, Cascino A, Giordano A. Antisense oligonucleotides as therapeutic agents. J Cell Physiol. 1999 Nov;181(2):251-7. Review. PubMed PMID: 10497304.

Galderisi U, Di Bernardo G, Cipollaro M, Jori FP, Piegari E, Cascino A, Peluso G, Melone MA. Induction of apoptosis and differentiation in neuroblastoma  and astrocytoma cells by the overexpression of Bin1, a novel Myc interacting protein. J Cell Biochem. 1999 Sep 1;74(3):313-22. PubMed PMID: 10412034.

Cipollaro M, Di Bernado G, Forte A, Galano G, De Masi L, Galderisi U, Guarino FM, Angelini F, Cascino A. Histological analysis and ancient DNA amplification of human bone remains found in caius iulius polybius house in pompeii. Croat Med J.  1999 Sep;40(3):392-7. PubMed PMID: 10411967.

Galderisi U, Di Bernardo G, Melone MA, Galano G, Cascino A, Giordano A, Cipollaro M. Antisense inhibitory effect: a comparison between 3'-partial and full phosphorothioate antisense oligonucleotides. J Cell Biochem. 1999 Jul 1;74(1):31-7. PubMed PMID: 10381259.

Galderisi U, Di Bernardo G, Cipollaro M, Peluso G, Cascino A, Cotrufo R, Melone MA. Differentiation and apoptosis of neuroblastoma cells: role of N-myc gene product. J Cell Biochem. 1999 Apr 1;73(1):97-105. PubMed PMID: 10088728.

Cipollaro M, Di Bernardo G, Galano G, Galderisi U, Guarino F, Angelini F, Cascino A. Ancient DNA in human bone remains from Pompeii archaeological site. Biochem Biophys Res Commun. 1998 Jun 29;247(3):901-4. PubMed PMID: 9647790.

Melone MA, Galderisi U, Iacomino G, Cipollaro M, Di Bernardo G, Cotrufo R, Peluso G, Cascino A. Antisense oligonucleotides and myotonin gene expression in C2 mouse cells. Antisense Nucleic Acid Drug Dev. 1998 Feb;8(1):25-33. PubMed PMID: 9512093.

Cipollaro M, Galderisi U, Iacomino G, Galano G, Di Bernardo G, Lus G, Cotrufo R, Orsini A, Santoro L, Pastore L, Sarrantonio C, Salvatore F, Cascino A. CTG repeat number in the nonaffected allele of myotonic dystrophy patients is not critical for disease expression. Hum Biol. 1997 Dec;69(6):887-90. PubMed PMID: 9353981.

Fucci L, Galderisi U, Piscopo M, del Gaudio R, Geraci G. In situ hybridization analysis of globin mRNAs in the primitive erythroid cells of the chick embryo. Experientia. 1996 Jun 15;52(6):535-9. PubMed PMID: 8698084.

Galderisi U, Cipollaro M, Melone MA, Iacomino G, Di Bernardo G, Galano G, Contrufo R, Zappia V, Cascino A. Myotonic dystrophy: antisense oligonucleotide inhibition of DMPK gene expression in vitro. Biochem Biophys Res Commun. 1996 Apr 25;221(3):750-4. PubMed PMID: 8630033.


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